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INTRODUCTION Cancer is a general term used to describe more than 100 distinct, mostly malignant diseases affecting many different tissues and cell types, characterized by the rapid growth of abnormal cells that results from the accumulation of a few inherited or environmentally-induced genetic mutations and epigenetic changes

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These effects extend beyond in vitro experiments

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Comment: While many commenters indicated that our proposed changes to the HPT requirements outlined in the CY 2026 OPPS/ASC proposed rule and/or the HPT requirements in general are burdensome, as discussed in prior sections of this final rule with comment period, only several commenters commented on our specific burden estimates for these information collections